Pharma Grade

Aromasin belongs to the category and class of drugs known as aromatase inhibitors (AIS). Aromatase inhibitors belong to an even wider group of drugs known as anti-estrogens. Another subgroup of the anti-estrogen drug is Selective Estrogen Receptor Modulators (SERMs) such as Nolvadex and Clomid. AIS and SERM form anti-estrogens. Aromatase inhibitors differ significantly from SERMs in both the action and management of estrogen control issues.

Aromasin is a very powerful non-steroidal aromatase inhibitor with the ability to reduce the level of estrogen aromatase by up to 85%. Suicidal aromatase inhibitors such as exemestane (Aromasin) are used to permanently inhibit and turn off the aromatase enzyme. This makes the enzymes always inactive. This means that Aromasin has the characteristic structure of four carbon cycloalkane rings common to all non-steroidal molecules. Exemestane, as a non-steroidal aromatase inhibitor, remains stably bound to the aromatase enzyme. Since the aromatase enzyme is strongly attracted to the steroidal androgenic structure (testosterone), it aromatizes to estrogen. The chemical structure of AROMASIN inhibits / disables the action of the aromatase enzyme. Because the binding strength is so great, this inhibition becomes constant for the aromatase enzyme with which Aromasin has been bound. A similar non-steroidal aromatase inhibitor, Formestane, exhibits the same properties (although it is much weaker than Aromasin). Thanks to this potency, there is absolutely no risk of aromatizing estrogen when the administration of Aromasin is suddenly stopped.

Aromasin (Exemestane) was originally designed by Pharmacia & Upjohn for the treatment of women with breast cancer, particularly postmenopausal patients, and has been used as adjunctive therapy after failure of other first line therapies (eg Nolvadex ™) for breast cancer. In 1999, the FDA approved the introduction of Exemestane to the prescription drug market, and in 2000 it was launched under the Aromasin brand. The sale of Aromasin has spread around the world and the drug is now used in almost every country in the world. The Aromasin brand, due to various patents and marketing rights, is currently the only officially produced and sold anti-aromatization product.